Each of the hundred billion neurons within the human brain builds connections, known as synapses, with more than thousand other neurons. But rather than this resulting in a chaotic system, the brain is wired in a specific and highly organised manner that we don’t yet fully understand.
Within the Quantitative Neurobiology Lab, we integrate structural biology, biophysics, and cell biology to resolve the molecular mechanisms and cellular principles underlying synapse assembly and neuronal network formation. We aim to increase fundamental knowledge on how we learn and forget. Ultimately, this may enable the development of medications that restore major brain functions in patients suffering from neurodegenerative disorders, including Alzheimer or Parkinson’s disease, or from developmental disorders such as autism.